Evolutionary Analysis of Ion Channel Domains

Screen Shot 2016-03-02 at 10.55.10 AMWe investigate the sequence-function relationships in ion channel domains with approaches from information theory and probabilistic modeling.

We collect a large number of unique domain sequences from diverse, long-diverged phylogenetic lineages and relate the statistical properties of this ensemble to functional constraints imposed by evolution.

The design principles we are able to infer rationalize existing experimental results and generate testable hypotheses.

E. Palovcak, L. Delemotte, M. L. Klein and V. Carnevale, J. Gen. Phys. 143, 145-156 (2014)